The Museum houses the collection of the "Evidence of Life", the legacy of Frenchtown's own historian, the late Richard Vinson. In addition, there is the Achelpohl, Ell, McKee-McAdam and Lindenwood collections, as well as other collections and items donated to the museum. The museum has the largest collection of late 19th and early 20th century African American studio photographs in the area
The Frenchtown Heritage Museum and Research Center is the recipient of the 2006 Historic Restoration & Architectural Design Award.
In 2005, the Museum's Heritage Garden received a Citation of Commendation from the First Capitol Garden Club. The Archie Scott Award for Preservation was awarded to the Museum in 2008 by the Missouri Alliance for Historic Preservation.